1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer
Identifieur interne : 001595 ( Main/Exploration ); précédent : 001594; suivant : 0015961-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer
Auteurs : Raquel Carvalho Montenegro [Brésil] ; Letícia Veras Lotufo [Brésil] ; Manoel Odorico De Moraes [Brésil] ; Cláudia Do Pessoa [Brésil] ; Felipe Augusto Rocha Rodrigues [Brésil] ; Marcelle De Lima Ferreira Bispo [Brésil] ; Camila Cataldi De Alcantara [Brésil] ; Carlos Roland Kaiser [Brésil] ; Marcus Vinícius Nora De Souza [Brésil]Source :
- Medicinal Chemistry Research [ 1054-2523 ] ; 2012-11-01.
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- topic : Cancer.
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Abstract
Abstract: Heteroaromatic derivatives (3a–f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) exhibited an excellent cytotoxic activity against the referred lines, and especially on melanoma cells (MDAMB-435). In this case, compound 3e is four times more active than the standard substance Doxorubicin. Together with other results from our group, 7-chloro-4-quinolinylhydrazones derived from chloroquine could be considered a relevant finding toward the rational design of new leads for antitumor compounds.
Url:
DOI: 10.1007/s00044-011-9894-8
Affiliations:
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type="eISSN">1554-8120</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>New York</pubPlace><date type="published" when="2012-11-01">2012-11-01</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="3615">3615</biblScope><biblScope unit="page" to="3619">3619</biblScope></imprint><idno type="ISSN">1054-2523</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1054-2523</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antitumor activity</term><term>Cancer</term><term>Chloroquine</term><term>Drugs</term><term>Hydrazones</term><term>Quinoline</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cancer</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Heteroaromatic derivatives (3a–f) have been synthesized and evaluated for their activity against four cancer cell lines. Among the studied compounds, 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine (3e) exhibited an excellent cytotoxic activity against the referred lines, and especially on melanoma cells (MDAMB-435). In this case, compound 3e is four times more active than the standard substance Doxorubicin. Together with other results from our group, 7-chloro-4-quinolinylhydrazones derived from chloroquine could be considered a relevant finding toward the rational design of new leads for antitumor compounds.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Ceará</li><li>Pará</li><li>État de Rio de Janeiro</li></region></list><tree><country name="Brésil"><region name="Pará"><name sortKey="Montenegro, Raquel Carvalho" sort="Montenegro, Raquel Carvalho" uniqKey="Montenegro R" first="Raquel Carvalho" last="Montenegro">Raquel Carvalho Montenegro</name></region><name sortKey="De Alcantara, Camila Cataldi" sort="De Alcantara, Camila Cataldi" uniqKey="De Alcantara C" first="Camila Cataldi" last="De Alcantara">Camila Cataldi De Alcantara</name><name sortKey="De Lima Ferreira Bispo, Marcelle" sort="De Lima Ferreira Bispo, Marcelle" uniqKey="De Lima Ferreira Bispo M" first="Marcelle" last="De Lima Ferreira Bispo">Marcelle De Lima Ferreira Bispo</name><name sortKey="De Lima Ferreira Bispo, Marcelle" sort="De Lima Ferreira Bispo, Marcelle" uniqKey="De Lima Ferreira Bispo M" first="Marcelle" last="De Lima Ferreira Bispo">Marcelle De Lima Ferreira Bispo</name><name sortKey="De Moraes, Manoel Odorico" sort="De Moraes, Manoel Odorico" uniqKey="De Moraes M" first="Manoel Odorico" last="De Moraes">Manoel Odorico De Moraes</name><name sortKey="De Souza, Marcus Vinicius Nora" sort="De Souza, Marcus Vinicius Nora" uniqKey="De Souza M" first="Marcus Vinícius Nora" last="De Souza">Marcus Vinícius Nora De Souza</name><name sortKey="De Souza, Marcus Vinicius Nora" sort="De Souza, Marcus Vinicius Nora" uniqKey="De Souza M" first="Marcus Vinícius Nora" last="De Souza">Marcus Vinícius Nora De Souza</name><name sortKey="Kaiser, Carlos Roland" sort="Kaiser, Carlos Roland" uniqKey="Kaiser C" first="Carlos Roland" last="Kaiser">Carlos Roland Kaiser</name><name sortKey="Lotufo, Leticia Veras" sort="Lotufo, Leticia Veras" uniqKey="Lotufo L" first="Letícia Veras" last="Lotufo">Letícia Veras Lotufo</name><name sortKey="Pessoa, Claudia Do" sort="Pessoa, Claudia Do" uniqKey="Pessoa C" first="Cláudia Do" last="Pessoa">Cláudia Do Pessoa</name><name sortKey="Rodrigues, Felipe Augusto Rocha" sort="Rodrigues, Felipe Augusto Rocha" uniqKey="Rodrigues F" first="Felipe Augusto Rocha" last="Rodrigues">Felipe Augusto Rocha Rodrigues</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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